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KMID : 0616120080390040357
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 4 p.357 ~ p.364
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Chemical Constituents of Saposhnikovia divaricata
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Kim So-Jun
Chin Young-Won
Yoon Kee-Dong
Ryu Min-Youl
Yang Min-Hye
Lee Je-Hyun
Kim Jin-Woong
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Abstract
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The roots of Saposhnikovia divaricata Schischk. (Umbelliferae) have been known to possess analgesic, anti-inflammatory,
anti-parasitic and anti-bacterial activities, and used for curing headaches, fever and arthralgia. In this study, we aimed
to isolate active constituents to provide phytochemical data for the quality control of this plant. Nine coumarins, eight
chromones, three sterols and a coumarolignan were isolated from EtOAc-soluble fraction of the roots of S. divaricata through repetive column chromatography method using silica gel, ODS gel, Sephadex-LH 20, MPLC and HPLC. By analyses of spectroscopic data and comparison of their data with those of published values, the compounds were identified as 3’-O-angeloylhamaudol (1), β-sitosterol (2), marmesin (3), phellopterin (4), anomalin (5), imperatorin (6), xanthotoxin (7), deltoin (8), bergapten (9), stigmasterol (10), ledebouriellol (11), hamaudol (12), 8’-epicleomiscosin A (13), xanthoarnol (14), cimifugin (15), 5-O-methylvisamminol (16), daucosterol (17), 4’-O-β-D-glucosyl-5-O-methylvisamminol (18), nodakenin (19), sec-O-glucosylhamaudol (20), prim-O-glucosylcimifugin (21). Among them, 8’-epicleomiscosin (13) was firstly reported from Umbelliferae family and xanthoarnol (14) and nodakenin (19) were isolated from this plant for the first time.
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KEYWORD
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Umbellifera, Saposhnikovia divaricata, coumarins, chromones, sterols, coumarolignan
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